Más Dermatología, n.º 37

Más Dermatol. 2022;37:7-11 doi:10.5538/1887-5181.2022.37.7 11 artículo de revisión Toxicodermias I Sánchez Vicens A et al. la presencia de incontinencia pigmentaria, con macrófagos melanófagos cargados de melanina en la dermis papilar. En las formas ampolloso-necróticas, pueden existir vesículas y ampollas subepidérmicas con necrosis de la epidermis suprayacente. El tratamiento es sintomático, con la supresión del fármaco y la administración de corticoides tópicos y antihistamínicos. Los corticoides orales se han usado en casos ampollosos graves, pero no alteran la evolución del cuadro. BIBLIOGRAFÍA 1. Roujeau JC, Bonnetblanc JM, Schmutz JL, Crickx B. Iatrogénie. Diagnostic et prévention. Toxidermies médicamenteuses. Ann Dermatol Venereol. 2002;129(10 Suppl):S163-9. 2. Demoly P, Hillaire-Buys D. Classification and epidemiology of hypersensitivity drug reactions. Immunol Allergy Clin North Am. 2004;24(3):345-56. 3. Field TS, Gurwitz JH, Avorn J, McCormick D, Jain S, Eckler M, et al. Risk factors for adverse drug events among nursing home residents. Arch Intern Med. 2001;161(13):1629-34. 4. The diagnosis and management of anaphylaxis. Joint Task Force on Practice Parameters, American Academy of Allergy, Asthma and Immunology, American College of Allergy, Asthma and Immunology, and the Joint Concil of Allergy, Asthma and Immunology. J Allergy Clin Immunol. 1998;101(6 Pt 2):S465-528. 5. Bigby M, Jick S, Jick H, Arndt K. Drug-induced cutaneous reactions. A report from the Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982. JAMA. 1986;256(24):3358-63. 6. Bourrain JL. Toxidermies. Ann Dermatol Venereol. 2019;146(11): 740-55. 7. Nespoulous L, Matei I, Charissoux A, Bédane C, Assikar S. Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) associated with pristinamycin, secnidazole, and nefopam, with a review of the literature. Contact Dermatitis. 2018; 79(6):378-80. 8. Huynh T, Hughey LC, McKay K, Carney C, Sami N. Systemic drug-related intertriginous and flexural exanthema from radio contrast media: a series of 3 cases. JAAD Case Rep. 2015;1(3): 147-9. 9. Tan SC, Tan JWL. Symmetrical drug-related intertriginous and flexural exanthema. Curr Opin Allergy Clin Immunol. 2011; 11(4):313-8. 10. Mizukawa Y, Yamazaki Y, Teraki Y, Hayakawa J, Hayakawa K, Nuriya H, et al. Direct evidence for interferon-gamma production by effector-memory-type intraepidermal T cells residing at an effector site of immunopathology in fixed drug eruption. Am J Pathol. 2002;161(4):1337-47.

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